Is TMC1 the Hair Cell Mechanotransducer Channel?
نویسندگان
چکیده
منابع مشابه
The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.
Sound stimuli are converted into electrical signals via gating of mechano-electrical transducer (MT) channels in the hair cell stereociliary bundle. The molecular composition of the MT channel is still not fully established, although transmembrane channel-like protein isoform 1 (TMC1) may be one component. We found that in outer hair cells of Beethoven mice containing a M412K point mutation in ...
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Throughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the cells. The anomalous MS channels are responsible for the reverse-pola...
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Hair cells in the vertebrate cochlea are arranged tonotopically with their characteristic frequency (CF), the sound frequency to which they are most sensitive, changing systematically with position. Single mechanotransducer channels of hair cells were characterized at different locations in the turtle cochlea. In 2.8 mM external Ca2+, the channel's chord conductance was 118 pS (range 80-163 pS)...
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B. Pan1, J Waguespack3, M.E. Schnee1, C., LeBlanc3., A.J. Ricci1,2* 3 1 -Department of Otolaryngology, Stanford University, 300 Pasteur Dr. Stanford CA 94305 4 2-Department of Molecular and Cellular Physiology Stanford University, 300 Pasteur Dr. 5 Stanford CA 94305 6 3Neuroscience Centerat Louisiana State Health Sciences Center, 2020 Gravier St New Orleans 7 LA 70125 8 Corresponding author: An...
متن کاملFM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel.
Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy indicates that dye entry is rapid and via the apical surface. Cooling to 4 degrees C and high extracellular calcium both reduce dye loading. Pretreatment with EGTA, a condition that breaks tip links and prevents mechanotr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.05.032